Imipramine belongs to the class of tricyclic antidepressants (TCAs). This medication is used to treat major depression, panic disorder and enuresis (inability to control urination). Imipramine can be also applied for other purposes.

        Take Tofranil by mouth with a glass of water, with or without food. Take the drug only as prescribed because dosage and schedule may vary depending on your condition and other factors. Avoid cutting, crushing or chewing this medicine. Do not take the medicine more often than it is prescribed. Do not give up taking it except on the advice of your doctor. It may need time for medicine to help. Consult your doctor concerning the proper dose for you.

        Before taking Imipramine to tell your doctor or chemist if you are allergic to it; or if you have other allergies. Inform your doctor or chemist if you have bipolar confusion, eye, liver or kidney problems. Avoid drinking alcohol and smoking while being treated with this medication. Aged people can be more sensitive to the side effects of the medicine. During the pregnancy, this treatment should be used only when strongly necessary. As this medicament can be absorbed by skin, women who are pregnant or may become pregnant should not manipulate this medicine.

        Tofranil should not be used by pregnant/nursing women or children as well as by the patients having demonstrated a reaction of hypersensitivity to Imipramine.

The most common side effects are:

• dizziness, 

• drowsiness,

• lightheadedness,

• confusion, 

• agitation, 

• increased anxiety, etc. 

        A very serious allergic reaction rarely occurs. Many people using this medicine do not have serious side effects. Turn to your doctor or pharmacist for more details. In case you notice the effects not listed here, contact your doctor or pharmacist.

        Tell your doctor or pharmacist of all prescription and nonprescription/herbal products you used before using this medication. Imipramine can interact with: * MAO inhibitors: Furazolidone, Isocarboxazid, Linezolid, Moclobemide Tranylcypromine, etc. * Anti-arrhythmic medication: Propafenone, Quinidine, etc. * Selective Serotonin Reuptake Inhibitors (SSRIs): Citalopram, Dapoxetine, Fluoxetine, Fluvoxamine, Paroxetine, etc. * Antipsychotics (also called neuroleptics): Fluphenazine, etc. * H2-receptor antagonists: Cimetidine, Ranitidine, Famotidine, Nizatidine. Turn to your doctor or pharmacist for more details.

        If you have missed your dose, take it as soon as you remember. If you see that it is near the time for the next dose, skip the missed dose and resume your usual dosing schedule. Do not take your dose twice.

        If you think you have used too much of this medicine seek emergency medical attention right away. The symptoms of overdose usually include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting.

        Store your medicines at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture. Do not store your drugs in the bathroom. Keep all drugs away from reach of children and pets.